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1

Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract

Yu, Alex, Baker, Jason R., Fioritto, Ann F., Wang, Ying, Luo, Ruijuan, Li, Siwei, Wen, Bo, Bly, Michael, Tsume, Yasuhiro, Koenigsknecht, Mark J., Zhang, Xinyuan, Lionberger, Robert, Amidon, Gordon L.,

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 3.32 MB

english, 2017

2

Gastrointestinal Motility and Luminal pH Influence in Vivo Dissolution and Systemic Absorption of Drug Product in Human Gastrointestinal Tract Under Fed and Fasted Conditions

Koenigsknecht, Mark, Baker, Jason, Fioritto, Ann F., Tsume, Yasuhiro, Wen, Bo, Dickens, Joseph, Yu, Alex, Wysocki, Jeffery, Shedden, Kerby, Bleske, Barry, Lee, Allen, Hasler, William L., Amidon, Gordo

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 1.40 MB

english, 2017

3

Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time

Yu, Alex, Jackson, Trachette, Tsume, Yasuhiro, Koenigsknecht, Mark, Wysocki, Jeffrey, Marciani, Luca, Amidon, Gordon L., Frances, Ann, Baker, Jason R., Hasler, William, Wen, Bo, Pai, Amit, Sun, Duxin

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 2.02 MB

english, 2017

4

Corrigendum: Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

Mathewson, Nathan D, Jenq, Robert, Mathew, Anna V, Koenigsknecht, Mark, Hanash, Alan, Toubai, Tomomi, Oravecz-Wilson, Katherine, Wu, Shin-Rong, Sun, Yaping, Rossi, Corinne, Fujiwara, Hideaki, Byun, Ja

Journal:

Nature Immunology

Year:

2016

Language:

english

File:

PDF, 116 KB

english, 2016

5

Low Buffer Capacity and Alternating Motility Along The Human Gastrointestinal Tract: Implications for In Vivo Dissolution and Absorption of Ionizable Drugs

Hens, Bart, Tsume, Yasuhiro, Bermejo, Marival, Paixao, Paulo, Koenigsknecht, Mark, Baker, Jason R., Hasler, William L., Lionberger, R., Fan, Jianghong, Dickens, Joseph, Shedden, Kerby A., Wen, Bo, Wys

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 1.80 MB

english, 2017

6

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach

Paixão, Paulo, Bermejo, Marival, Hens, Bart, Tsume, Yasuhiro, Dickens, Joseph, Shedden, Kerby, Salehi, Niloufar, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, J

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.50 MB

english, 2018

7

Thiamine biosynthesis can be used to dissect metabolic integration

Mark J. Koenigsknecht, Diana M. Downs

Journal:

Trends in Microbiology

Year:

2010

Language:

english

File:

PDF, 288 KB

english, 2010

8

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

Theriot, Casey M., Koenigsknecht, Mark J., Carlson, Paul E., Hatton, Gabrielle E., Nelson, Adam M., Li, Bo, Huffnagle, Gary B., Z. Li, Jun, Young, Vincent B.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

9

Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract

Koenigsknecht, Mark J., Theriot, Casey M., Bergin, Ingrid L., Schumacher, Cassie A., Schloss, Patrick D., Young, Vincent B., McCormick, B. A.

Journal:

Infection and Immunity

Year:

2015

Language:

english

File:

PDF, 1.62 MB

english, 2015

10

Glutamine Phosphoribosylpyrophosphate Amidotransferase-independent Phosphoribosyl Amine Synthesis from Ribose 5-Phosphate and Glutamine or Asparagine

Koenigsknecht, Mark J., Ramos, Itzel, Downs, Diana M.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 736 KB

english, 2007

11

Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection

Koenigsknecht, Mark J., Young, Vincent B.

Journal:

Current Opinion in Gastroenterology

Year:

2013

Language:

english

File:

PDF, 203 KB

english, 2013

12

Tu1358 Novel Technique for Gastrointestinal Fluid Isolation and Microbiome Analysis Following Administration of Different Mesalamine Formulations in Healthy Volunteers

Koenigsknecht, Mark, Fioritto, Ann F., Baker, Jason, Bleske, Barry, Young, Vincent B., Hasler, William L., Sun, Duxin

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 446 KB

english, 2015

13

Mo1224 Contrasting Regional Availability of Different Mesalamine Products in the Gastrointestinal Tract in Healthy Humans Using a Novel Multi-Port Luminal Aspiration System and Correlation With Systemic Absorption

Fioritto, Ann F., Baker, Jason, Collins, Kristen, Wen, Bo, Wang, Ying, Luo, Ruijuan, Bleske, Barry, Johnson, Mark, Koenigsknecht, Mark, Hasler, William L., Sun, Duxin

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 789 KB

english, 2015

14

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

Mathewson, Nathan D, Jenq, Robert, Mathew, Anna V, Koenigsknecht, Mark, Hanash, Alan, Toubai, Tomomi, Oravecz-Wilson, Katherine, Wu, Shin-Rong, Sun, Yaping, Rossi, Corinne, Fujiwara, Hideaki, Byun, Ja

Journal:

Nature Immunology

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

15

Mo1318 Direct Comparison of In Vivo Drug Release Profiles of Three Locally-Acting Drug Products of Mesalamine in the Gastrointestinal Tract and Correlation With Systemic Exposure and Fecal Concentrations in Healthy Humans

Fioritto, Ann F., Yu, Alex, Baker, Jason, Collins, Kristen, Wen, Bo, Wang, Ying, Luo, Ruijuan, Li, Siwei, Bleske, Barry, Johnson, Mark, Koenigsknecht, Mark, Hasler, William L., Sun, Duxin

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 434 KB

english, 2016

16

The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation

Dahl, Jan-Ulrik, Gray, Michael J., Bazopoulou, Daphne, Beaufay, Francois, Lempart, Justine, Koenigsknecht, Mark J., Wang, Ying, Baker, Jason R., Hasler, William L., Young, Vincent B., Sun, Duxin, Jako

Journal:

Nature Microbiology

Year:

2017

Language:

english

File:

PDF, 757 KB

english, 2017

17

NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Chen, Liang, Wilson, Justin E, Koenigsknecht, Mark J, Chou, Wei-Chun, Montgomery, Stephanie A, Truax, Agnieszka D, Brickey, W June, Packey, Christopher D, Maharshak, Nitsan, Matsushima, Glenn K, Plevy

Journal:

Nature Immunology

Year:

2017

Language:

english

File:

PDF, 3.00 MB

english, 2017

18

Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Chen, Liang, Wilson, Justin E, Koenigsknecht, Mark J, Chou, Wei-Chun, Montgomery, Stephanie A, Truax, Agnieszka D, Brickey, W June, Packey, Christopher D, Maharshak, Nitsan, Matsushima, Glenn K, Plevy

Journal:

Nature Immunology

Year:

2017

Language:

english

File:

PDF, 72 KB

english, 2017

19

Corrigendum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Chen, Liang, Wilson, Justin E, Koenigsknecht, Mark J, Chou, Wei-Chun, Montgomery, Stephanie A, Truax, Agnieszka D, Brickey, W June, Packey, Christopher D, Maharshak, Nitsan, Matsushima, Glenn K, Plevy

Journal:

Nature Immunology

Year:

2017

Language:

english

File:

PDF, 59 KB

english, 2017

20

Sa1561 - Standardizing Parameters of Fasting Duodenojejunal Manometry in Healthy Volunteers Using Clustered High-Resolution Pressure Ports: Focus on Migrating Motor Complex Phase 2 Contractions

Hasler, William L., Baker, Jason, Dickens, Joseph, Koenigsknecht, Mark, Frances, Ann, Lee, Allen, Shedden, Kerby, Harer, Kimberly, Amidon, Gordon, Sun, Duxin

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 587 KB

english, 2018

21

Perturbations in Histidine Biosynthesis Uncover Robustness in the Metabolic Network of Salmonella enterica

Koenigsknecht, Mark J., Lambrecht, Jennifer A., Fenlon, Luke A., Downs, Diana M., de Crécy-Lagard, Valerie

Journal:

Year:

2012

Language:

english

File:

PDF, 427 KB

english, 2012

22

Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State

Bermejo, Marival, Paixão, Paulo, Hens, Bart, Tsume, Yasuhiro, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Dickens, Joseph, Shedden, Kerby A., Wen,

Journal:

Molecular Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

23

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans—Part 2: Fed State

Paixão, Paulo, Bermejo, Marival, Hens, Bart, Tsume, Yasuhiro, Dickens, Joseph, Shedden, Kerby, Salehi, Niloufar, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, J

Journal:

Molecular Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 2.76 MB

english, 2018

24

Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors

Baker, Jason R, Dickens, Joseph R, Koenigsknecht, Mark, Frances, Ann, Lee, Allen A, Shedden, Kerby A, Brasseur, James G, Amidon, Gordon L, Sun, Duxin, Hasler, William L

Journal:

Journal of Neurogastroenterology and Motility

Year:

2019

Language:

english

File:

PDF, 848 KB

english, 2019

25

Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans

Seekatz, Anna M., Schnizlein, Matthew K., Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Bleske, Barry E., Young, Vincent B., Sun, Duxin, McMahon, Katherine

Journal:

Year:

2019

File:

PDF, 1.52 MB

2019

26

Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution

Yu, Alex, Koenigsknecht, Mark J., Hens, Bart, Baker, Jason R., Wen, Bo, Jackson, Trachette L., Pai, Manjunath P., Hasler, William, Amidon, Gordon L., Sun, Duxin

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 1.17 MB

2020